Permissive hypercapnia and permissive hypoxemia in neonates

Permissive hypercapnia.

Mechanical ventilation using high tidal volume (VT) and transpulmonary pressure can damage the lung, causing ventilator-induced lung injury. Permissive hypercapnia, a ventilatory strategy for acute respiratory failure in which the lungs are ventilated with a low inspiratory volume and pressure, has been accepted progressively in critical care for adult, pediatric, and neonatal patients requirin...

Bench-to-bedside review: Permissive hypercapnia

Current protective lung ventilation strategies commonly involve hypercapnia. This approach has resulted in an increase in the clinical acceptability of elevated carbon dioxide tension, with hypoventilation and hypercapnia 'permitted' in order to avoid the deleterious effects of high lung stretch. Advances in our understanding of the biology of hypercapnia have prompted consideration of the pote...

Permissive hypercapnia and risk for brain injury and developmental impairment.

OBJECTIVE Permissive hypercapnia is a respiratory-care strategy that is used to reduce the risk for lung injury. The goal of this study was to evaluate whether permissive hypercapnia is associated with higher risk for intraventricular hemorrhage and early childhood behavioral and functional problems than normocapnia among very low birth weight infants. METHODS Very low birth weight infants fr...

Permissive hypercapnia: finding its place in clinical care.

Severe status asthmaticus: management with permissive hypercapnia and inhalation anesthesia.

OBJECTIVE To describe the difficulties that can be encountered during mechanical ventilation of severe status asthmaticus and to discuss the safety of permissive hypercapnia as a ventilatory strategy and the role and limitations of inhalation anesthesia in the treatment of refractory cases. DESIGN Case series and review of literature. SETTING Intensive care unit of a tertiary care hospital....